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EXPERT HUB

FUNDAMENTAL SCIENCE

The foundation for the development of 

effective treatments for neurodegenerative diseases

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Expertise

#drugdiscovery  #pharmacology 

Sophie is a Senior Lecturer at the University of Glasgow's Institute of Molecular, Cell and Systems Biology and a member of the Scottish Dementia Research Consortium Executive Committee. 

 

Research within Sophie's laboratory is focussed on defining the therapeutic potential of G protein-coupled receptors (GPCR) in neurodegenerative diseases, such as Alzheimer’s disease.

 

Specifically, the lab aim to exploit this family of cell-surface receptors to modulate neuroinflammatory processes, and in doing so, offer an approach for modifying progression of disease.

Working with a network of academic and industrial partners  Sophie's group employ an array of experimental approaches which span through novel pharmacology to (chemo)genetic and neurodegenerative disease mouse models.

Dr Sophie Bradley
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#pharmacology 

#neuroinflammation

#prion

Miriam Scarpa is a PhD student at the Centre for Translational Pharmacology at the University of Glasgow.

 

Miriam's project is funded by an MRC-CASE studentship in collaboration with Eli Lilly and Company, and supervised by Dr Sophie Bradley, Prof Andrew Tobin and Dr Zeshan Ahmed.

 

Miriam's research focusses on the role of G protein-Coupled Receptors (GPCRs) – particularly the M1 muscarinic acetylcholine receptor (mAChR) – in the progression of neurodegenerative conditions such as Alzheimer’s disease. Her studies employ a wide range of laboratory techniques from in vitro pharmacology to animal behaviour using the prion mouse model to recapitulate neurodegenerative disease.

Miriam Scarpa
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#neuroimaging 

#vascular

#stroke

#machinelearning

#cognition

Fraser Sneden

Fraser is a PhD student within the Institute of Cardiovascular and Medical Sciences at the University of Glasgow. He is working on data from the XILO-FIST clinical trial, a study which investigates the affect of allopurinol on long-term outcomes following ischaemic stroke.


Fraser is interested in exploring the relationship between carotid artery structure, brain structure and cognition in ischaemic stroke, and developing an automated tool that will estimate vascular parameters of carotid structure including stenosis.

 

Additionally, he aims to investigate any effects allopurinol has on carotid artery structure, including percentage of stenosis and intima-media thickness

DIAGNOSIS

Research to discover or improve methods to allow neurodegenerative diseases to be detected earlier and more accurately.

LIVING WITH DEMENTIA

Research to improve understanding of the experience of living with dementia and all aspects of dementia care and caring

PREVENTION

Focussing on the prevention of neurodegenerative diseases and their progression to develop symptoms as observed in dementia

INFORMATICS

Coordinated approach to integrate neurodegenerative diseases data from all real world clinical and research sources  across Scotland

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